You are here: Home Faculty C. Jane Welsh
Document Actions
C. Jane Welsh

C. Jane Welsh

Professor

Veterinary Integrative Biosciences

204 VMR
4458 TAMU

College Station , TX 77843-4458
Office Phone: (979) 862-4974

Education:

  1. B.Sc., Microbiology, University of London, UK, 1976
  2. Ph.D., Biochemistry/Immunology, University of London, UK, 1981
  3. Postdoc., Liver Unit, University of London, 1979-1981
  4. Postdoc., University of Cambridge, 1982-1989

Biography:

We are investigating the mechanisms by which viruses initiate neurological and autoimmune diseases. Specifically we are studying the neuropathogenesis of Theiler’s virus-induced demyelination (TVID) as a model for multiple sclerosis (MS).  The blood-brain barrier (BBB) is broken down prior to relapses in MS and therefore we are investigating the role of the BBB in the neuropathogenesis of TVID. Relapses in MS have been associated with stressful life events and we are examining the effect of stress on both acute and persistent viral infections of the central nervous system. We are also investigating various therapeutic regimens for the treatment of MS.

Selected Publications:

Welsh, C.J., Steelman, A.J., Mi, W., Young, C.R., Storts, R., Welsh, T.H., Jr., and Meagher, M.W. 2009. Neuroimmune interactions in a model of multiple sclerosis. Ann N Y Acad Sci 1153: 209-219.

Steelman, A.J., Dean, D.D., Young, C.R., Smith, R., 3rd, Prentice, T.W., Meagher, M.W., and Welsh, C.J. 2009. Restraint stress modulates virus specific adaptive immunity during acute Theiler's virus infection. Brain Behav Immun 23: 830-843.

Steelman, A.J., Alford, E., Young, C.R., Welsh, T.H., Meagher, M.W., and Welsh, C.J. 2009. Restraint Stress Fails to Render C57BL/6 Mice Susceptible to Theiler's Virus-Induced Demyelination. Neuroimmunomodulation 17: 109-119.

Young, E.E., Prentice, T.W., Satterlee, D., McCullough, H., Sieve, A.N., Johnson, R.R., Welsh, T.H., Welsh, C.J., and Meagher, M.W. 2008. Glucocorticoid exposure alters the pathogenesis of Theiler's murine encephalomyelitis virus during acute infection. Physiol Behav 95: 63-71.

Steelman, A., Dean, D., Young, C.R., Smith, R., Meagher, M., and Welsh, J. 2008. Effects of restraint stress on adaptive immune responses to acute Theiler's virus infection in SJL mice. Journal of Neuroimmunology 203: 152-152.

Dean, D., Steelman, A., Arenas-Gamboa, A., Rice-Ficht, A., Young, C., Bazer, F., Burghardt, R., and Welsh, C.J. 2008. Immunomodulation of Theiler's virus-induced demyelination [TVID] using encapsulated ovine interferon-tau [IFNT]: The novel administration of a novel type IIFN in an animal model of multiple sclerosis [MS]. Journal of Neuroimmunology 203: 144-144.

Steelman, A., Prentice, T., Young, C., Dean, D., Hammons, A., Meagher, M., and Welsh, J. 2007. The effects of restraint stress (RS) on immune responses to Theiler's murine encephalomyelitis virus (TMEV) in SJL mice. Faseb Journal 21: A1393-A1393.

Meagher, M.W., Johnson, R.R., Young, E.E., Vichaya, E.G., Lunt, S., Hardin, E.A., Connor, M.A., and Welsh, C.J. 2007. Interleukin-6 as a mechanism for the adverse effects of social stress on acute Theiler's virus infection. Brain Behav Immun 21: 1083-1095.

Meagher, M.W., Johnson, R.R., Vichaya, E.G., Young, E.E., Lunt, S., and Welsh, C.J. 2007. Social conflict exacerbates an animal model of multiple sclerosis. Trauma Violence & Abuse 8: 314-330.

Fuller, A., Yahikozawa, H., So, E.Y., Dal Canto, M., Koh, C.S., Welsh, C.J., and Kim, B.S. 2007. Castration of male C57L/J mice increases susceptibility and estrogen treatment restores resistance to Theiler's virus-induced demyelinating disease. Journal of Neuroscience Research 85: 871-881.

Villarreal, D., Young, C.R., Storts, R., Ting, J.W., and Welsh, C.J. 2006. A comparison of the neurotropism of Theiler's virus and poliovirus in CBA mice. Microb Pathog 41: 149-156.

Sieve, A.N., Steelman, A.J., Young, C.R., Storts, R., Welsh, T.H., Welsh, C.J., and Meagher, M.W. 2006. Sex-dependent effects of chronic restraint stress during early Theiler's virus infection on the subsequent demyelinating disease in CBA mice. J Neuroimmunol 177: 46-62.

Mi, W., Young, C.R., Storts, R.W., Steelman, A.J., Meagher, M.W., and Welsh, C.J. 2006. Restraint stress facilitates systemic dissemination of Theiler's virus and alters its pathogenecity. Microb Pathog 41: 133-143.

Mi, W., Prentice, T.W., Young, C.R., Johnson, R.R., Sieve, A.N., Meagher, M.W., and Welsh, C.J. 2006. Restraint stress decreases virus-induced pro-inflammatory cytokine mRNA expression during acute Theiler's virus infection. J Neuroimmunol 178: 49-61.

Johnson, R.R., Prentice, T.W., Bridegam, P., Young, C.R., Steelman, A.J., Welsh, T.H., Welsh, C.J., and Meagher, M.W. 2006. Social stress alters the severity and onset of the chronic phase of Theiler's virus infection. J Neuroimmunol 175: 39-51.

Welsh, J., Mi, W., Johnson, R., Steelman, A., Sieve, A., Young, C., Storts, R., Welsh, T., and Meagher, M. 2004. Impact of stressors on disease resistance of different genotypes. Journal of Animal Science 82: 40-40.

Welsh, C.J., Bustamante, L., Nayak, M., Welsh, T.H., Dean, D.D., and Meagher, M.W. 2004. The effects of restraint stress on the neuropathogenesis of Theiler's virus infection II: NK cell function and cytokine levels in acute disease. Brain Behav Immun 18: 166-174.

Sieve, A.N., Steelman, A.J., Young, C.R., Storts, R., Welsh, T.H., Welsh, C.J., and Meagher, M.W. 2004. Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice. J Neuroimmunol 155: 103-118.

Mi, W., Belyavskyi, M., Johnson, R.R., Sieve, A.N., Storts, R., Meagher, M.W., and Welsh, C.J. 2004. Alterations in chemokine expression following Theiler's virus infection and restraint stress. J Neuroimmunol 151: 103-115.

Johnson, R.R., Storts, R., Welsh, T.H., Jr., Welsh, C.J., and Meagher, M.W. 2004. Social stress alters the severity of acute Theiler's virus infection. J Neuroimmunol 148: 74-85.

Park, Y., Rangel, C., Reynolds, M.M., Caldwell, M.C., Johns, M., Nayak, M., Welsh, C.J., McDermott, S., and Datta, S. 2003. Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division. Dev Biol 253: 247-257.

Girvin, A.M., Gordon, K.B., Welsh, C.J., Clipstone, N.A., and Miller, S.D. 2002. Differential abilities of central nervous system resident endothelial cells and astrocytes to serve as inducible antigen-presenting cells. Blood 99: 3692-3701.

Tennakoon, D.K., Smith, R., Stewart, M.D., Spencer, T.E., Nayak, M., and Welsh, C.J. 2001. Ovine IFN-tau modulates the expression of MHC antigens on murine cerebrovascular endothelial cells and inhibits replication of Theiler's virus. J Interferon Cytokine Res 21: 785-792.

Campbell, T., Meagher, M.W., Sieve, A., Scott, B., Storts, R., Welsh, T.H., and Welsh, C.J. 2001. The effects of restraint stress on the neuropathogenesis of Theiler's virus infection: I. Acute disease. Brain Behav Immun 15: 235-254.

Book Chapters:

Meagher, M.W. and Welsh, C.J.R. 2010. Social stress and inflammation in the exacerbation of multiple sclerosis: an animal model with implications for humans. In The Psychoneuroimmunology of Chronic Disease: Exploring the Links Between Inflammation, Stress and Illness (ed. K. Kendall-Tackett), pp. 159-181. American Psychological Association, Washington, DC.

Young, C.R. and Welsh, C.J.R. 2008. Animal models of multiple sclerosis. In Sourcebook of models for biomedical research (ed. P.M. Conn), pp. 665-676. Humana Press, New Jersey.

Welsh, C.J.R., Steelman, A.J., Sieve, A.N., Mi, W., Johnson, R.R., Young, C.R., Prentice, T.W., and Meagher, M.W. 2008. Neuroendocrine-immune interactions in neurotropic viral infections. In Neurotropic viral infections (ed. C. Shoshkes Reiss), pp. 300-314. Cambridge University Press.

Welsh, C.J.R., Mi, W., Sieve, A., Steelman, A., Johnson, R.R., Young, C.R., Prentice, T., Hammons, A., Storts, R., Welsh, T. et al. 2006. The effect of restraint stress on the neuropathogenesis of Theiler's virus-induced demyelination, a murine model for multiple sclerosis. In Neural and neuroendocrine mechanisms in host defense and autoimmunity (eds. C.J. Welsh M.W. Meagher, and E. Sternberg), pp. 190-225. Springer, New York.

Meagher, M.W., Johnson, R.R., Good, E., and Welsh, C.J. 2006. Social stress alters the severity of a virally initiated model of multiple sclerosis. In Fourth Edition of Psychoneuroimmunology (ed. R.A. Ader). Elsevier Inc, San Diego.

Welsh, C.J.R. and Young, C.R. 2006. Autoimmune processes in the Central Nervous System. In Neuroimmunology (eds. A. Galoyan and H. Besedovsky), pp. 333-354. Springer Science + Business Media, LLC.

Meagher, M.W., Johnson, R.R., Good, E., and Welsh, C.J. 2006. Social stress alters the severity of an animal model of multiple sclerosis. In Neural and neuroendocrine mechanisms in host defense and autoimmunity (eds. C.J. Welsh M.W. Meagher, and E. Sternberg), pp. 216-240. Springer, New York.

Books:

Welsh, C.J., Meagher, M.W., and Sternberg, E. 2006. Neural and neuroendocrine mechanisms in host defense and autoimmunity. Springer, New York.

Publications from Genetics Graduate Students:

Welsh, C.J., Steelman, A.J., Mi, W., Young, C.R., Storts, R., Welsh, T.H., Jr., and Meagher, M.W. 2009. Neuroimmune interactions in a model of multiple sclerosis. Ann N Y Acad Sci 1153: 209-219.

Welsh, C.J.R., Steelman, A.J., Sieve, A.N., Mi, W., Johnson, R.R., Young, C.R., Prentice, T.W., and Meagher, M.W. 2008. Neuroendocrine-immune interactions in neurotropic viral infections. In Neurotropic viral infections (ed. C. Shoshkes Reiss), pp. 300-314. Cambridge University Press.

Mi, W., Young, C.R., Storts, R.W., Steelman, A.J., Meagher, M.W., and Welsh, C.J. 2006. Restraint stress facilitates systemic dissemination of Theiler's virus and alters its pathogenecity. Microb Pathog 41: 133-143.

Mi, W., Prentice, T.W., Young, C.R., Johnson, R.R., Sieve, A.N., Meagher, M.W., and Welsh, C.J. 2006. Restraint stress decreases virus-induced pro-inflammatory cytokine mRNA expression during acute Theiler's virus infection. J Neuroimmunol 178: 49-61.

Welsh, C.J.R., Mi, W., Sieve, A., Steelman, A., Johnson, R.R., Young, C.R., Prentice, T., Hammons, A., Storts, R., Welsh, T. et al. 2006. The effect of restraint stress on the neuropathogenesis of Theiler's virus-induced demyelination, a murine model for multiple sclerosis. In Neural and neuroendocrine mechanisms in host defense and autoimmunity (eds. C.J. Welsh M.W. Meagher, and E. Sternberg), pp. 190-225. Springer, New York.

Mi, W., Belyavskyi, M., Johnson, R.R., Sieve, A.N., Storts, R., Meagher, M.W., and Welsh, C.J. 2004. Alterations in chemokine expression following Theiler's virus infection and restraint stress. J Neuroimmunol 151: 103-115.

Alumni:

Wentao Mi

Ashley Hammons

Courses:

VIBS 606 Neurobiology: Neurodegenerative Diseases
VTMI 662 Advanced Immunologic Concepts
GENE 681 Genetics Seminar
VIBS 650 Graduate Education