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E. Sally Ward

E. Sally Ward


Department of Molecular and Cellular Medicine and Department of Microbial Pathogenesis and Immmunology

Reynolds Medical Building
Room 469

College Station , TX 77807
Office Phone: (979) 862-7612


  1. B.A. with First Class Honours, Natural Sciences (Part II course, Biochemistry), University of Cambridge, UK, 1982
  2. Ph.D., Biochemistry, University of Cambridge, 1985


Sally Ward received her B.A. with First Class Honours in Natural Sciences (Part II course, Biochemistry), University of Cambridge, U.K., in 1982 and completed her Ph.D. in Biochemistry at the Department of Biochemistry, University of Cambridge, under the mentorship of Professor David J. Ellar in 1985. From 1988-1990 she held the Stanley Elmore Senior Medical Research Fellow at Sidney Sussex College, Cambridge whilst working with Sir Greg Winter at the MRC Laboratory of Molecular Biology, Cambridge, U.K. She became an Assistant Professor in 1990 at the University of Texas Southwestern Medical Center in Dallas.  Dr. Ward was promoted in 2002 to Professor in the Department of Immunology at UT Southwestern and was appointed to the Paul and Betty Meek-FINA Professorship in Molecular Immunology in 2004.  Dr. Ward joined the faculty at Texas A&M Health Science Center in September 2014.

Research Interests:

The Ward laboratory is run jointly with the laboratory of Dr. Raimund Ober. The research is directed towards taking a highly interdisciplinary approach to generate effective therapeutics for autoimmunity and cancer. This involves a combination of antibody/protein engineering, fluorescence microscopy and in vivo studies in mouse models of disease. These studies are funded by the National Institutes of Health, National Multiple Sclerosis Society, Cancer Prevention and Research Institute of Texas (CPRIT) and biopharma.


  • Ghetie, V., Hubbard, J. G., Kim, J. K., Tsen, M. F., Lee, Y., and Ward, E. S. (1996) Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice, Eur. J. Immunol., 26, 690-696. PMID: 8605939
  • Ghetie, V., Popov, S., Borvak, J., Radu, C., Matesoi, D., Medesan, C., Ober, R. J., and Ward, E. S. (1997) Increasing the serum persistence of an IgG fragment by random mutagenesis, Nat. Biotechnol., 15, 637-640. PMID: 9219265
  • Garcia, K. C., Radu, C. G., Ho, J., Ober, R. J., and Ward, E. S. (2001) Kinetics and thermodynamics of T cell receptor- autoantigen interactions in murine experimental autoimmune encephalomyelitis, Proc. Natl. Acad. Sci. USA, 98, 6818-6823. PMID:11391002
  • Ober, R. J., Martinez, C., Lai, X., Zhou, J., and Ward, E. S. (2004) Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level, Proc. Natl. Acad. Sci. USA, 101, 11076-11081. PMID: 15258288
  • Ober, R. J., Martinez, C., Vaccaro, C., Zhou, J., and Ward, E. S. (2004) Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn, J. Immunol., 172, 2021-2029. PMID: 14764666
  • Vaccaro, C., Zhou, J., Ober, R. J., and Ward, E. S. (2005) Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels, Nat. Biotechnol., 23, 1283-1288. PMID: 16186811
  • Vaccaro, C., Bawdon, R., Wanjie, S., Ober, R. J., and Ward, E. S. (2006) Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies, Proc. Natl. Acad. Sci. USA, 103, 18709-18714. PMID: 17116867
  • Prabhat, P., Gan, Z., Chao, J., Ram, S., Vaccaro, C., Gibbons, S., Ober, R. J., and Ward, E. S. (2007) Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, using multifocal plane microscopy, Proc. Natl. Acad. Sci. USA, 104, 5889-5894. PMID: 17384151
  • Perez-Montoyo, H., Vaccaro, C., Hafner, M., Ober, R. J., Mueller, W., and Ward, E. S. (2009) Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice, Proc. Natl. Acad. Sci. USA, 106, 2788-2793. PMID: 19188594
  • Patel., D.A., Puig Canto, A., Challa, D.K., Perez Montoyo, H., Ober, R.J. and Ward, E.S. (2011) Neonatal Fc receptor blockade by Fc engineering ameliorates arthritis in a murine model, J. Immunol., 187, 1015-1022. PMID: 21690327
  • Gan, Z., Ram, S., Ober, R.J. and Ward, E.S. (2013) Using multifocal plane microscopy to reveal novel trafficking processes on the recycling pathway, J. Cell Sci., 126, 1176-1188. PMID: 23345403
  • Chao, J., Ram, S., Ward, E.S. and Ober, R.J. (2013) Ultrahigh accuracy imaging modality for super-localization microscopy, Nat. Methods, 10, 335-338. PMID: 23455923
  • Bansal, P., Khan, T., Bussmeyer, U., Challa, D.K., Swiercz, R., Velmurugan, R., Ober, R.J. and Ward, E.S. (2013) The encephalitogenic, human myelin oligodendrocyte glycoprotein-induced antibody repertoire is directed toward multiple epitopes in C57BL/6 mice, J. Immunol., 191, 1091- 1101. PMID: 23817425
  • Poovassery, J. S., Kang J. C., Kim, D., Ober, R. J., Ward, E. S. (2014) Antibody targeting of HER2/HER3 signaling overcomes heregulin-induced resistance to PI3K inhibition in prostate cancer, Int. J. Cancer, 2014 Dec 4. doi: 10.1002/ijc.29378. [Epub ahead of print] PMID: 25471734
  • Swiercz, R., Chiguru, S., Tahmasbi, A., Ramezani, S. M., Hao, G., Challa, D. K., Lewis, M. A., Kulkarni, P. V., Sun, X., Ober, R. J., Mason, R. P., and Ward, E. S. (2014) Use of Fc-engineered antibodies as clearing agents to increase contrast during PET, J.Nucl. Med., 55, 1204-1207. PMID: 24868106