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Robert S. Chapkin

Robert S. Chapkin

Distinguished Professor, Regents Professor and University Faculty Fellow

Program in Integrative Nutrition & Complex Diseases

Department of Nutrition and Food Science

111 Cater Mattil Hall
2253 TAMU

College Station , TX 77843-2253
Office Phone: (979) 845-0419

Education:

  1. B.S., Nutrition and Biochemistry, University of Guelph, 1981
  2. M.S., Nutrition, University of Guelph, 1983
  3. Ph.D., Nutrition and Physiological Chemistry, University of California-Davis, 1986
  4. Postdoc., Cell Biology, University of California-Davis, 1986-1988

Biography:

Dr. Robert Chapkin is a member of the Program in Integrative Nutrition & Complex Diseases, and Deputy Director of the NIEHS Center for Translational Environmental Health Research at Texas A&M University. He received his BS in Nutrition and Biochemistry from the University of Guelph, Ontario, Canada; an MS in Nutrition from the University of Guelph, 1983, and a PhD in Nutrition and Physiology Chemistry from the University of California-Davis in 1986. After completing a postdoctoral fellowship in Cancer Biology in the School of Medicine at the University of California-Davis in 1988, he joined the faculty at Texas A&M University.

Dr. Chapkin is currently a Distinguished Professor, Regents Professor and University Faculty Fellow and during the past 26 years has published over 220 peer-reviewed articles in nutrition, membrane biology, cancer biology, non-invasive biomarkers and immunology.  He holds appointments in the Departments of Nutrition & Food Science, Biochemistry & Biophysics, Veterinary Integrated Biosciences, and Molecular Pathogenesis & Immunology.

Dr. Chapkin is an expert in environmental modulators related to chemoprevention of colon cancer and chronic inflammatory diseases, e.g., inflammatory bowel disease.  He has been continuously funded by NIH/NCI for the past 25 years and has made highly significant contributions to T cell/inflammation biology and cancer chemoprevention in five specific areas: (i) membrane biology and nutritional modulation of epithelia/immune cell membrane structure and function, (ii) establishment of models for chronic inflammation and cancer prevention studies, (iii) elucidation of signal transduction processes in intestinal stem cells, (iv) investigation of the role of inflammation as a critical factor in cancer development, and its modulation by diet, and (v) development of novel noninvasive Systems Biology-based methodologies to assess crosstalk between the gut microbiome and the host transcriptome and its application to translational research. He serves as the Deputy Director of the P30 NIEHS sponsored Texas A&M Center for Translational Environmental Health Research (CTEHR) and coordinates the Quantitative Biology Core.

 

Selected Publications from a total of 228:

L.A. Davidson, D.V. Nguyen, R.M. Hokanson, E.S. Callaway, R.B. Isett, N.D. Turner, E.R. Dougherty, N. Wang, J.R. Lupton, R.J. Carroll and R.S. Chapkin.  Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat.  Cancer Research 64:6797-6804, 2004.

C. Zhao, I. Ivanov, E.R. Dougherty, T.J. Hartman, E. Lanza, N.H. Colburn, J.R. Lupton, L.A. Davidson and R.S. Chapkin.  Non-invasive detection of candidate molecular biomarkers in subjects with a history of insulin resistance and colorectal adenomas.  Cancer Prevention Research 2:590-597, 2009.  PMCID: PMC2745241

L.A. Davidson, N. Wang, I. Ivanov, J. Goldsby, J.R. Lupton and R.S. Chapkin.  Identification of actively translated mRNA transcripts in a rat model of early stage colon carcinogenesis.  Cancer Prevention Research 2:984-994, 2009. PMCID: PMC2783859

L.A. Davidson, N. Wang, M.S. Shah, I. Ivanov, J.R. Lupton and R.S. Chapkin.  n-3 polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon.  Carcinogenesis 30:2077-2084, 2009. PMCID: PMC2792315

C. Zhao, M.L. Bittner, R.S. Chapkin and E.R. Dougherty.  Characterization of the effectiveness of reporting lists of small feature sets relative to the accuracy of the prior biological knowledge.  Cancer Informatics 9:4960, 2010.  PMCID: PMC2865771

R.S. Chapkin, C. Zhao, I. Ivanov, L.A. Davidson, J.S. Goldsby, J.R. Lupton, R.A. Mathai, M. Siegel, D. Rai, M. Russell, S.M. Donovan and E.R. Dougherty.  Non-invasive stool-based detection of infant gastrointestinal development using gene expression profiles from exfoliated epithelial cells.  American Journal of Physiology 298:G582-G589, 2010. PMCID: PMC2867429

M. Shah, S.L. Schwartz, C. Zhao, L.A. Davidson, B. Zhou, J.R. Lupton, I. Ivanov and R.S. Chapkin.  Integrated microRNA and mRNA expression profiling in a rat colon carcinogenesis model: Effect of a chemoprotective diet.  Physiological Genomics 43:640-654, 2011. PMID:21406606

J.M. Monk, W. Kim, E. Callaway, W. He, B. Weeks, R.C. Alaniz, D.N. McMurray and R.S. Chapkin. Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARδ in inflammation-induced colon carcinogenesis.  American Journal of Physiology – GI Physiology 302:G153-G167, 2012.  PMID:21940900

L.A. Davidson, J.S. Goldsby, E.S. Callaway, N. Barker and R.S. Chapkin.  Alteration of colonic stem cell signatures during the regenerative response to injury.  Biochmicia et Biophysica Acta-Molecular Basis of Disease 1822:1600-1607, 2012. PMID: 22750333

H.F. Turk, R. Barhoumi and R.S. Chapkin.  Alteration of EGFR spatiotemporal dynamics suppresses signal transduction.  PLoS One 7(6):e39682, June, 2012.  doi:10.1371/journal.pone.0039682 PMCID: PMC3384615

J.M. Monk, T.Y. Hou, H.F. Turk, B. Weeks, C. Wu, D.N. McMurray and R.S. Chapkin..  Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis.  PLoS One 7(11)e49739, November, 2012. doi:10.1371/journal.pone.0049739.  PMCID:PMC3500317

S. Schwartz, I. Friedberg, I.V. Ivanov, L.A. Davidson, J.S. Goldsby, D.B. Dahl, D. Herman, M. Wang, S.M. Donovan and R.S. Chapkin. A Metagenomic study of diet-dependent interaction between gut microflora and host in infants reveals differences in developmental and immune responses.  Genome Biology 13:R32 doi:10.1186/gb-2012-13-4-r32.

U.H. Jin, S.O. Lee, G. Sridharan, K. Lee, L.A. Davidson, A. Jayaraman, R.S. Chapkin, R. Alaniz and S. Safe.  Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities.  Molecular Pharmacology 85:777-788, 2014. PMID:24563545.

J.M. Knight, L.A. Davidson, D. Herman, C.R. Martin, J.S. Goldsby, I.V. Ivanov, S.M. Donovan and R.S. Chapkin.  Non-invasive analysis of intestinal development in premature and full term infants using RNA-Sequencing.  Scientific Reports Nature 4:5453; DOI:10.1038/srep05453 (2014).  PMID:24965658

S.M. Donovan, M. Wang, M.H. Monaco, C.R. Martin, L.A. Davidson, I. Ivanov and R.S. Chapkin.  Noninvasive molecular fingerprinting of host microbiome interaction in neonates.  FEBS Letters (In Press).

Publications from Genetics Graduate Students:

Davidson, L.A., Wang, N., Shah, M.S., Lupton, J.R., Ivanov, I., and Chapkin, R.S. 2009. n-3 Polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon. Carcinogenesis 30: 2077-2084.

Shah, M.S., Davidson, L.A., Ivanov, I., Wang, N., Lupton, J.R., and Chapkin, R.S. 2009. Establishment of a cell culture model to examine dietary regulation of microRNA expression in the colon.  Presented at the Keystone Symposia on "MicroRNA and Cancer", Breckenridge, CO, June 10-15, 2009.

Shah, M., S.L. Schwartz, C. Zhao, L.A. Davidson, B. Zhou, J.R. Lupton, I. Ivanov and R.S. Chapkin. 2011.  Integrated microRNA and mRNA expression profiling in a rat colon carcinogenesis model: Effect of a chemoprotective diet.  Physiological Genomics 43:640-654. PMID:21406606

Alumni:

Manasvi Shah

Research Interests:

Bioinformatics and Genomics:

Role of Dietary and Microbial Ligands as Modifiers of Inflammation and Cancer Development