- B.S., Texas A&M University, Animal Science, 1978
- M.S., Texas A&M University, Animal Nutrition, 1984
- Ph.D., Texas A&M University, Nutrition, 1995
In 1996 I started working to identify compounds in the diet that were capable of mediating the initiation, promotion and progression of colon cancer. Most of the work has addressed the role of dietary fiber and the bioactive molecules in fiber-containing foods on mitigation of various aspects of colon carcinogenesis and inflammatory bowel disease. Current research is designed to understand how bioactive compounds influence the intestinal environment, with particular attention to the interaction between the microbiota and the colon epithelia. Efforts are focused on understanding the regulators of signaling between microbiota and epithelial cells through toll-like receptors and their down-stream effects on the regulation of expression of inflammatory mediators. Disease initiators/promoters used in our studies have included chemical carcinogens, galactic cosmic radiation (Brookhaven National Laboratory), and pro-inflammatory agents. The research has produced 54 peer-reviewed papers and book chapters, and one co-edited book entitled “Potential Health Benefits of Citrus”.
George, N.I., Lupton, J.R., Turner, N.D., Chapkin, R.S., Davidson, L.A., and Wang, N. Evaluation of fecal mRNA reproducibility via a marginal transformed Mixture modeling approach. BMC Bioinformatics 11: 13.
Warren, C.A., Paulhill, K.J., Davidson, L.A., Lupton, J.R., Taddeo, S.S., Hong, M.Y., Carroll, R.J., Chapkin, R.S., and Turner, N.D. 2009. Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis. J Nutr 139: 101-105.
Haussler, D., O'Brien, S.J., Ryder, O.A., Barker, F.K., Clamp, M., Crawford, A.J., Hanner, R., Hanotte, O., Johnson, W.E., McGuire, J.A. et al. 2009. Genome 10K: A Proposal to Obtain Whole-Genome Sequence for 10 000 Vertebrate Species. Journal of Heredity 100: 659-674.
Vanamala, J., Glagolenko, A., Yang, P., Carroll, R.J., Murphy, M.E., Newman, R.A., Ford, J.R., Braby, L.A., Chapkin, R.S., Turner, N.D. et al. 2008. Dietary fish oil and pectin enhance colonocyte apoptosis in part through suppression of PPARdelta/PGE2 and elevation of PGE3. Carcinogenesis 29: 790-796.
Swartz, M.D., Mo, Q.X., Murphy, M.E., Lupton, J.R., Turner, N.D., Hong, M.Y., and Vannucci, M. 2008. Bayesian Variable Selection in Clustering High-Dimensional Data With Substructure. Journal of Agricultural Biological and Environmental Statistics 13: 407-423.
Crim, K.C., Sanders, L.M., Hong, M.Y., Taddeo, S.S., Turner, N.D., Chapkin, R.S., and Lupton, J.R. 2008. Upregulation of p21Waf1/Cip1 expression in vivo by butyrate administration can be chemoprotective or chemopromotive depending on the lipid component of the diet. Carcinogenesis 29: 1415-1420.
Baladandayuthapani, V., Mallick, B.K., Young Hong, M., Lupton, J.R., Turner, N.D., and Carroll, R.J. 2008. Bayesian hierarchical spatially correlated functional data analysis with application to colon carcinogenesis. Biometrics 64: 64-73.
Apanasovich, T.V., Ruppert, D., Lupton, J.R., Popovic, N., Turner, N.D., Chapkin, R.S., and Carroll, R.J. 2008. Aberrant crypt foci and semiparametric modeling of correlated binary data. Biometrics 64: 490-500.
Li, Y.H., Wang, N., Hong, M.Y., Turner, N.D., Lupton, J.R., and Carroll, R.J. 2007. Nonparametric estimation of correlation functions in longitudinal and spatial data, with application to colon carcinogenesis experiments. Annals of Statistics 35: 1608-1643.
Vanamala, J., Leonardi, T., Patil, B.S., Taddeo, S.S., Murphy, M.E., Pike, L.M., Chapkin, R.S., Lupton, J.R., and Turner, N.D. 2006. Suppression of colon carcinogenesis by bioactive compounds in grapefruit. Carcinogenesis 27: 1257-1265.
Current Genetics Students: