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Nancy H. Ing

Nancy H. Ing

Associate Professor

Department of Animal Science

Department of Veterinary Integrative Biosciences

410 Kleberg Building
2471 TAMU

College Station , TX 77843-2471
Office Phone: (979) 862-2790

Education:

  1. B.S., Zoology, University of Florida, 1979
  2. D.V.M., University of Florida, 1984
  3. Ph.D., Biochemistry and Molecular Biology, University of Florida, 1988
  4. Postdoc., Cell Biology, Baylor College of Medicine, 1992

Biography:

Dr. Nancy H. Ing is an Associate Professor in the Department of Animal Science and has a joint appointment with the Department of Veterinary Integrative Biosciences. She is an active member of the Faculties of Genetics, of Reproductive Biology and of Biotechnology.  Her research interests focus on understanding how hormones regulate gene expression in animal tissues. Current research projects investigate stress hormone effects on gene expression in the stallion testes and estrogen effects on tumor growth in dogs.


Dr. Ing has serves as an ad hoc and panel reviewers of competitive USDA grant proposals for Enhancing Reproductive Efficiency and for NSF grant proposals for Integrative Animal Systems. Professional memberships include the Endocrine Society, Society for Reproductive Medicine, Society for the Study of Reproduction, American Society of Animal Science, Phi Beta Kappa, Gamma Sigma Delta, and Phi Zeta.

Dr. Ing received a bachelor's in Zoology in 1979, a D.V.M. in 1984, and a doctorate in Biochemistry and Molecular Biology in 1988, all from the University of Florida. She completed Postdoctoral work in Cell Biology in 1992 at Baylor College of Medicine. Both Ph.D and Postdoctoral mentors (R. Michael Roberts and Bert W. O'Malley, respectively) are members of the National Academy of Sciences.

Selected Publications:

Faucette, A. N., V. A. Maher, M. A. Gutierrez, J. M. Jucker, D. C. Yates, T. H. Welsh, Jr., M. Amstalden, G. R. Newton, L. C. Nuti, D. W. Forrest, and N. H. Ing. 2014. Temporal changes in histomorphology and gene expression in goat testes during postnatal development. J. Anim. Sci. (in press)

Ing, N. H., S. P. Brinsko, K. O. Curley, D. W. Forrest, C. C. Love, K. Hinrichs, M. M Vogelsang, D. D. Varner, and T. H. Welsh, Jr. 2014. Dexamethasone acutely regulates  endocrine parameters in stallions and subsequently affects gene expression in testicular germ cells. Anim. Reprod. Sci. (in press).

Ing. N. H.,  D. W. Forrest, P. K. Riggs, S. Loux, C. C. Love, S. P. Brinsko, D. D. Varner, and T. H. Welsh, Jr. 2014. Dexamethasone acutely down-regulates genes involved in steroidogenesis in stallion testes. J. Steroid Biochem. Mol. Biol. (in press).

Ing, N.H., D. Abi-Ghanem, M.M.K Abbas, A. Kaushik, L. Berghman, and J. B. Puschett. 2014. Marinobufagenin regulates permeability and gene expression of human brain microvascular endothelial cells. J. Am. Phys. 306:R918-924.

Ing, N. H., D. W. Forrest, C. C. Love, and D. D. Varner. 2014. Dense spermatozoa in stallion ejaculates contain lower concentrations of mRNAs encoding the sperm specific calcium channel 1, ornithine decarboxylase antizyme 3, aromatase and estrogen recptor alpha than less dense sperm. Theriogenology  DOI: 10.1016/j.theriogenology.2014.04.016.

Loux, S., K. R. Crawford, N. H. Ing, L. Gonsalez-Fernandez, B. Macias-Garcia, C. C. Love, D. D. Varner, I. C. Velez, Y.-H Choi, and K. Hinrichs. 2013. CatSper and the relationship of hyperactivated motility to calcium and pH kinetics. Biol Reprod  89:123.

Ing, N. H. 2010. Estradiol up-regulates expression of the A + U-rich binding factor 1 gene in the sheep uterus. J. Steroid Biochem. Mol. Biol. 122: 172-179. PMID:20621185

Laughlin, A., T. H. Welsh Jr., C. C. Love, D. D. Varner, A. R. Parrish, D. W. Forrest, and N. H. Ing. 2009. In vitro culture of precision-cut testicular tissue as a novel tool for the study of responses to LH. In Vitro Cell Dev. Biol. – Animal 46:45-53.  PMID:19915939

Mortensen, C.J., Choi, Y.H., Hinrichs, K., Ing, N.H., Kraemer, D.C., Vogelsang, S.G., and Vogelsang, M.M. 2009. Embryo recovery from exercised mares. Anim Reprod Sci 110: 237-244.

Massuto, D.A., Kneese, E.C., Johnson, G.A., Burghardt, R.C., Hooper, R.N., Ing, N.H., and Jaeger, L.A. 2009. Transforming growth factor beta (TGFB) signaling is activated during porcine implantation: Proposed role for latency associated peptide-integrins at the conceptus-maternal interface. Reproduction.

Laughlin, A.M., Welsh, T.H., Jr., Love, C.C., Varner, D.D., Parrish, A.R., Forrest, D.W., and Ing, N.H. 2009. In vitro culture of precision-cut testicular tissue as a novel tool for the study of responses to LH. In Vitro Cell Dev Biol Anim.

Ing, N.H., Massuto, D.A., and Jaeger, L.A. 2008. Estradiol up-regulates AUF1p45 binding to stabilizing regions within the 3'-untranslated region of estrogen receptor alpha mRNA. J Biol Chem 283: 1764-1772. PMID:18029355

Ing, N.H., Wolfskill, R.L., Clark, S., DeGraauw, J.A., and Gill, C.A. 2006. Steroid hormones acutely regulate expression of a Nudix protein-encoding gene in the endometrial epithelium of sheep. Mol Reprod Dev 73: 967-976. http://www3.interscience.wiley.com/cgi-bin/fulltext/112613568/PDFSTART

Jaeger, L.A., Spiegel, A.K., Ing, N.H., Johnson, G.A., Bazer, F.W., and Burghardt, R.C. 2005. Functional effects of transforming growth factor beta on adhesive properties of porcine trophectoderm. Endocrinology 146: 3933-3942.

Ing, N.H. 2005. Steroid hormones regulate gene expression posttranscriptionally by altering the stabilities of messenger RNAs. Biol Reprod 72: 1290-1296.

Ing, N.H. and Zhang, Y. 2004. Cell-specific expression of estrogen-responsive genes in the uteri of cyclic, early pregnant and ovariectomized ewes. Theriogenology 62: 403-414.

Ing, N.H., Laughlin, A.M., Varner, D.D., Welsh, T.H., Jr., Forrest, D.W., Blanchard, T.L., and Johnson, L. 2004. Gene expression in the spermatogenically inactive "dark" and maturing "light" testicular tissues of the prepubertal colt. J Androl 25: 535-544. PMID:15223842

Mitchell, D.C. and Ing, N.H. 2003. Estradiol stabilizes estrogen receptor messenger ribonucleic acid in sheep endometrium via discrete sequence elements in its 3'-untranslated region. Mol Endocrinol 17: 562-574.

Farnell, Y.Z. and Ing, N.H. 2003. The effects of estradiol and selective estrogen receptor modulators on gene expression and messenger RNA stability in immortalized sheep endometrial stromal cells and human endometrial adenocarcinoma cells. J Steroid Biochem Mol Biol 84: 453-461.

Farnell, Y.Z. and Ing, N.H. 2003. Endometrial effects of selective estrogen receptor modulators (SERMs) on estradiol-responsive gene expression are gene and cell-specific. J Steroid Biochem Mol Biol 84: 513-526.

Farnell, Y.Z. and Ing, N.H. 2003. Myometrial effects of selective estrogen receptor modulators on estradiol-responsive gene expression are gene and cell-specific. J Steroid Biochem Mol Biol 84: 527-536.

Robertson, J.A., Farnell, Y., Lindahl, L.S., and Ing, N.H. 2002. Estradiol up-regulates estrogen receptor messenger ribonucleic acid in endometrial carcinoma (Ishikawa) cells by stabilizing the message. J Mol Endocrinol 29: 125-135.

Farnell, Y.Z. and Ing, N.H. 2002. Estradiol and a selective estrogen receptor modulator affect steroid hormone receptor messenger RNA levels and turnover in explant cultures of sheep endometrium. In Vitro Cell Dev Biol Anim 38: 595-600.

Publications from Genetics Graduate Students:

Ing, N.H. and Zhang, Y. 2004. Cell-specific expression of estrogen-responsive genes in the uteri of cyclic, early pregnant and ovariectomized ewes. Theriogenology 62: 403-414.

Mitchell, D.C. and Ing, N.H. 2003. Estradiol stabilizes estrogen receptor messenger ribonucleic acid in sheep endometrium via discrete sequence elements in its 3'-untranslated region. Mol Endocrinol 17: 562-574.

Farnell, Y.Z. and Ing, N.H. 2003. The effects of estradiol and selective estrogen receptor modulators on gene expression and messenger RNA stability in immortalized sheep endometrial stromal cells and human endometrial adenocarcinoma cells. J Steroid Biochem Mol Biol 84: 453-461.

Farnell, Y.Z. and Ing, N.H. 2003. Endometrial effects of selective estrogen receptor modulators (SERMs) on estradiol-responsive gene expression are gene and cell-specific. J Steroid Biochem Mol Biol 84: 513-526.

Farnell, Y.Z. and Ing, N.H. 2003. Myometrial effects of selective estrogen receptor modulators on estradiol-responsive gene expression are gene and cell-specific. J Steroid Biochem Mol Biol 84: 527-536.

Robertson, J.A., Farnell, Y., Lindahl, L.S., and Ing, N.H. 2002. Estradiol up-regulates estrogen receptor messenger ribonucleic acid in endometrial carcinoma (Ishikawa) cells by stabilizing the message. J Mol Endocrinol 29: 125-135.

Farnell, Y.Z. and Ing, N.H. 2002. Estradiol and a selective estrogen receptor modulator affect steroid hormone receptor messenger RNA levels and turnover in explant cultures of sheep endometrium. In Vitro Cell Dev Biol Anim 38: 595-600.

Grants arising from Preliminary Data Generated by Genetics Graduate Students:

USDA National Research Initiatives Competitive Research Program, 2002-2004, "Oligonucleotides modulate estrogen receptor up-regulation in sheep uterus: makes sense!"

National Science Foundation Faculty Early Career Development Award, 1996-2002, "Physiological regulation of estrogen receptor gene expression by estrogen"

Alumni:

Yuhua Zhang-Farnell

Research Interests:

Bioinformatics and Genomics:

Steroid hormone action on reproductive tissues in mammals

Medical Genetics - Human and Animal:

Steroid hormone action on reproductive tissues in mammals

Molecular, Cellular and Developmental Genetics:

Steroid hormone action on reproductive tissues in mammals

Courses:

ANSC 626/GENE 626 Gene Expression
ANSC 654/VTPP 654 Molecular Endocrinology