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William Murphy

William Murphy


Department of Veterinary Integrative Biosciences

4458 TAMU
College Station , TX 77843-4458
Office Phone: (979) 458-0906


  1. B.S., Biological Sciences, Illinois State University, 1992
  2. Ph.D., Biological Science, Tulsa University, 1997


Research Interests:

Mammalian phylogenetics and molecular evolution, Feline evolutionary genomics, Y chromosome evolution, Genetics of hybrid sterility.

Selected Publications:

Meredith, R. W., Janecka, J. E., Gatesy, J., Ryder, O. A., Fisher, C. A., Teeling, E. C., Goodbla, A., Eizirik, E., Sim?o, T. L. L., Stadler, T., Rabosky, D. L., Honeycutt, R. L., Flynn, J. J., Ingram, C. M., Steiner, C., Williams, T. L., Robinson, T. J., Burk-Herrick, A., Westerman, M., Ayoub, N. A., Springer, M. S., and W. J. Murphy. 2011. Impacts of the Cretaceous Terrestrial Revolution and KPg Extinction on mammal diversification. Science.  In press.

Mason, V.C., Li, G., Helgen, K. M., and W. J. Murphy. 2011. Efficient cross-species capture hybridization and next-generation DNA sequencing of mitochondrial genomes from non-invasively sampled museum specimens. Genome Research In press (October 2011 issue).

Janecka, J.E., Jackson, R.M., Munkhtsog, B., Mallon, D.P., Naranbaatar, G., and W.J. Murphy. 2011. Comparison of noninvasive genetic and camera-trapping techniques for surveying snow leopards. Journal of Mammalogy  92: 771-783.

Li, G., Janecka, J.E., and W. J. Murphy. 2011. Accelerated evolution of CES7, a gene encoding a novel major urinary protein in the cat family. Molecular Biology and Evolution 28: 911-920.

Davis, B.W., Li, G., and W.J. Murphy. 2010. Reconciling the evolutionary radiation of the big cats (Panthera) using a Y chromosome supermatrix and a critical reanalysis of mitochondrial DNA. Molecular Phylogenetics and Evolution  56: 64-76.

Hayden, S., Bekaert, M., Crider, T., Mariani, S., Murphy, W.J., and E.C. Teeling. 2010. Ecological adaptation determines functional mammalian olfactory subgenomes.  Genome Research  20: 1-9.Miller, W., Drautz, D.I., Janecka, J.E., Lesk, A.M., Ratan, A., Tomsho, L.P., Packard, M., Zhang, Y., McClellan, L.R., Qi, J. et al. 2009. The mitochondrial genome sequence of the Tasmanian tiger (Thylacinus cynocephalus). Genome Research 19: 213-220.

Haussler, D., O'Brien, S.J., Ryder, O.A., Barker, F.K., Clamp, M., Crawford, A.J., Hanner, R., Hanotte, O., Johnson, W.E., McGuire, J.A. et al. 2009. Genome 10K: A Proposal to Obtain Whole-Genome Sequence for 10 000 Vertebrate Species. Journal of Heredity 100: 659-674.

Meredith, R. W., Gatesy, J., Murphy, W. J., Ryder, O. A., and M. S. Springer. 2009. Molecular decay of the tooth gene enamelin (ENAM) mirrors the loss of enamelin in placental mammals. PLoS Genetics  5: e1000634.

Davis, B.W., Raudsepp, T., Wilkerson, A.J.P., Agarwala, R., Schaffer, A.A., Houck, M., Chowdhary, B.P., and Murphy, W.J. 2009. A high-resolution cat radiation hybrid and integrated FISH mapping resource for phylogenomic studies across Felidae. Genomics 93: 299-304.

Wilkerson, A.J.P., Raudsepp, T., Graves, T., Albracht, D., Warren, W., Chowdhary, B.P., Skow, L.C., and Murphy, W.J. 2008. Gene discovery and comparative analysis of X-degenerate genes from the domestic cat Y chromosome. Genomics 92: 329-338.

Springer, M.S., Meredith, R.W., Eizirik, E., Teeling, E., and Murphy, W.J. 2008. Morphology and placental mammal phylogeny. Systematic Biology 57: 499-503.

Pearks-Wilkerson, A.J., Raudsepp, T., Graves, T., Albracht, D., Warren, W., Chowdhary, B.P., Skow, L.C., and Murphy, W.J. 2008. Gene discovery and comparative analysis of X-degenerate genes from the domestic cat Y chromosome. Genomics 92: 329-338.

Janecka, J.E., Jackson, R., Yuquang, Z., Diqiang, L., Munkhtsog, B., Buckley-Beason, V., and Murphy, W.J. 2008. Population monitoring of snow leopards using noninvasive collection of scat samples: a pilot study. Animal Conservation 11: 401-411.

Janecka, J.E., Helgen, K.M., Lim, N.T.L., Baba, M., Izawa, M., and Murphy, W.J. 2008. Evidence for multiple species of Sunda colugo. Current Biology 18: R1001-R1002.

Springer, M.S., Burk-Herrick, A., Meredith, R., Eizirik, E., Teeling, E., O'Brien, S.J., and Murphy, W.J. 2007. The adequacy of morphology for reconstructing the early history of placental mammals. Systematic Biology 56: 673-684.

Murphy, W.J., Pringle, T.H., Crider, T.A., Springer, M.S., and Miller, W. 2007. Using genomic data to unravel the root of the placental mammal phylogeny. Genome Research 17: 413-421.

Janecka, J.E., Miller, W., Pringle, T.H., Wiens, F., Zitzmann, A., Helgen, K.M., Springer, M.S., and Murphy, W.J. 2007. Molecular and genomic data identify the closest living relative of primates. Science 318: 792-794.

Murphy, W.J., Wilkerson, A.J.P., Raudsepp, T., Agarwala, R., Schaffer, A.A., Stanyon, R., and Chowdhary, B.P. 2006. Novel gene acquisition on carnivore Y chromosomes. Plos Genetics 2: e43.

Kohn, M.H., Murphy, W.J., Ostrander, E.A., and Wayne, R.K. 2006. Genomics and conservation genetics. Trends in Ecology & Evolution 21: 629-637.

Johnson, W. E., Eizirik, E., Pecon-Slattery, J., Murphy, W. J., Antunes, A., Teeling, E. C., and S. J. O?Brien. 2006. The late Miocene radiation of modern Felidae: a genetic assessment. Science 311: 73-77.

Murphy, W. J., Larkin, D., Everts van-der Wind, A., Bourque, G., Tesler, G., Auvil, L., Beever, J. E., Chowdhary, B. P., Galibert, F., Gatzke, L., Hitte, C., Meyers, S. N., Ostrander, E. A., Pape, G., Parker, H. G., Raudsepp, T., Rogatcheva, M. B., Schook, L. B., Skow, L. C., Welge, M., Womack, J. E., O'Brien, S. J., Pevzner, P. A., H. A. Lewin. 2005. Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps. Science 309: 613-617.

Teeling, E.C., Springer, M.S., Madsen, O., Bates, P., O'Brien, S.J., and Murphy, W.J. 2005. A molecular phylogeny for bats illuminates biogeography and the fossil record. Science 307: 580-584.

Murphy, W.J., Larkin, D.M., Everts-van der Wind, A., Bourque, G., Tesler, G., Auvil, L., Beever, J.E., Chowdhary, B.P., Galibert, F., Gatzke, L. et al. 2005. Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps. Science 309: 613-617.

Roca, A.L., Bar-Gal, G.K., Eizirik, E., Helgen, K.M., Maria, R., Springer, M.S., O'Brien, S.J., and Murphy, W.J. 2004. Mesozoic origin for West Indian insectivores. Nature 429: 649-651.

Murphy, W.J., Pevzner, P.A., and O'Brien, S.J. 2004. Mammalian phylogenomics comes of age. Trends in Genetics 20: 631-639.

Springer, M.S., Murphy, W.J., Eizirik, E., and O'Brien, S.J. 2003. Placental mammal diversification and the Cretaceous-Tertiary boundary. Proceedings of the National Academy of Sciences of the United States of America 100: 1056-1061.

Murphy, W.J., Eizirik, E., O'Brien, S.J., Madsen, O., Scally, M., Douady, C.J., Teeling, E., Ryder, O.A., Stanhope, M.J., de Jong, W.W. et al. 2001. Resolution of the early placental mammal radiation using Bayesian phylogenetics. Science 294: 2348-2351.

Murphy, W. J., Eizirik, E., Johnson, W. J., Zhang, Y. P., Ryder, O. A., and S. J. O'Brien. 2001.  Molecularphylogenetics and the origins of placental mammals. Nature  409:614-618.



BIMS 320/GENE 320 Biomedical Genetics