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Jerome Menet

Jerome Menet

Assistant Professor

Department of Biology

Interdisciplinary Life Sciences Building Room 3141A
3474 TAMU


College Station , TX 77843-3474
Office Phone: (979) 458-8599

Education:

  1. B.Sc., 1996, Sciences and Technology University of Lille (Lille, France), Molecular and Cellular Biology
  2. M.Sc., 1999, Louis Pasteur University (Strasbourg, France), Neurosciences
  3. Ph.D., 2003, Louis Pasteur University (Strasbourg, France), Neurosciences
  4. Postdoctoral Research, Brandeis University

Biography:

Research Interests

Molecular Underpinnings of the Circadian Clock in Mouse

Most organisms from bacteria to humans exhibit 24-hours rhythms in their biochemistry, physiology and behavior. Best exemplified by the sleep/wake cycle, these rhythms are remarkably widespread and include in humans hormonal (e.g., melatonin, insulin, cortisol), metabolic (e.g., glucose, cholesterol), physiological and behavioral oscillations. In fact, most biological functions are rhythmic and are set to perform optimally at the most appropriate time of the day. For example, the human digestion process performs better during the day when we are supposed to eat.

These circadian rhythms are generated by “molecular clocks”, which consist of a few “clock genes” interacting in feedback loops, and which drive the rhythmic expression of a large number of genes, i.e. ~10% of the transcriptome in any tissues. This wide impact of clock genes in regulating gene expression is underscored by the surprisingly large number of pathologies developed by clock-deficient mice. In addition to being arrhythmic, these mice indeed develop pathologies as diverse as mania-like behaviors, learning and memory defects, depression, drug addiction, insomnia, metabolic diseases, arthropathy, hematopoiesis defects and cancers.

Research in our lab aims at characterizing how circadian clocks and clock genes regulate gene expression to provide insights into how and why clock dysfuntion leads to a wide spectra of pathologies. To this end, we are using a wide-range of molecular and biochemical techniques to investigate the circadian clock function at the genome-wide level (e.g., next-generation sequencing). We are currently extending some of our recent results and focus on 1) how clock genes rhythmically regulate chromatin environment and 2) the mechanisms involved in rhythmic post-transcriptional regulation of gene expression.

Recent Publications

  1. Menet JS & Hardin PE (2014) Circadian clocks: the tissue is the issue. Curr Biol 24:R25-7 Full text
  2. Menet JS, Pescatore S & Rosbash M (2014) CLOCK:BMAL1 is a pioneer-like transcription factor. Genes Dev 28:8-13 Full text
  3. Rodriguez J, Tang CH, Khodor YL, Vodala S, Menet JS & Rosbash M (2013) Nascent-Seq analysis of Drosophila cycling gene expression. Proc Natl Acad Sci U S A 110:E275-84 Full text
  4. Menet JS, Rodriguez J, Abruzzi KC & Rosbash M (2012) Nascent-Seq reveals novel features of mouse circadian transcriptional regulation. Elife 1:e00011 Full text
  5. Khodor YL, Menet JS, Tolan M & Rosbash M (2012) Cotranscriptional splicing efficiency differs dramatically between Drosophila and mouse. RNA 18:2174-86 Full text
  6. Rodriguez J, Menet JS & Rosbash M (2012) Nascent-seq indicates widespread cotranscriptional RNA editing in Drosophila. Mol Cell 47:27-37 Full text
  7. Abruzzi KC, Rodriguez J, Menet JS, Desrochers J, Zadina A, Luo W, Tkachev S & Rosbash M (2011) Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. Genes Dev 25:2374-86 Full text
  8. Menet JS & Rosbash M (2011) When brain clocks lose track of time: cause or consequence of neuropsychiatric disorders. Curr Opin Neurobiol 21:849-57 Full text
  9. Menet JS, Abruzzi KC, Desrochers J, Rodriguez J & Rosbash M (2010) Dynamic PER repression mechanisms in the Drosophila circadian clock: from on-DNA to off-DNA. Genes Dev 24:358-67 Full text
  10. Kadener S, Menet JS, Sugino K, Horwich MD, Weissbein U, Nawathean P, Vagin VV, Zamore PD, Nelson SB & Rosbash M (2009) A role for microRNAs in the Drosophila circadian clock. Genes Dev 23:2179-91 Full text

Current Genetics Students:

Ben Greenwall

Alexandra Trott

 

Research Interests:

Bioinformatics and Genomics:

Regulation of rhythmic gene expression by the circadian clock in the mouse

Medical Genetics - Human and Animal:

Regulation of rhythmic gene expression by the circadian clock in the mouse

Molecular, Cellular and Developmental Genetics:

Regulation of rhythmic gene expression by the circadian clock in the mouse