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Clinton D. Allred

Clinton D. Allred

Assistant Professor

Department of Nutrition and Food Science

Room 214B Cater Mattil Hall
2253 TAMU

College Station , TX 77843-2253
Office Phone: (979) 845-0863

Education:

  1. B.S., Animal Science, University of Georgia, 1997
  2. Ph.D., Nutritional Sciences, University of Illinois, 2002
  3. Postdoc., Pharmacology, University of Kentucky College of Medicine, 2002-2006

Biography:

Dr. Clinton Allred is an assistant professor in the Department of Nutrition and Food Science at Texas A&M University.  He is currently serving as the Faculty Advisor to the Genetics Graduate Student Association.  Dr. Allred received his B.S. in Animal Science from the University of Georgia in 1997.  He completed his Ph.D. in nutrition at the University of Illinois in 2002.  He then served as a postdoctoral fellow in the department of pharmacology at the University of Kentucky College of Medicine until August of 2006.

Research Interests:

Estrogen as a Chemo-preventative Agent of Colon Cancer.  We are interested in the role of estrogen receptor beta (ERb) in colon cancer development and growth.  A clear correlation has been established between increased estrogen exposure and a decreased risk of colon tumor formation.  We are interested in elucidating whether ERb modulates the protective effects of estrogen in colon cells.  We are utilizing both molecular and animal modeling approaches to determine the physiological actions of estrogen on non-cancerous colon cells.  This is critical because our data suggest that estrogen prevents colon cancer by acting on these cells before they become cancerous.  In addition, we are using these models to define the role of dietary phytoestrogens in these systems.

Selected Publications:

Weige, C.C., Allred, K.F., and Allred, C.D. 2009. Estradiol alters cell growth in nonmalignant colonocytes and reduces the formation of preneoplastic lesions in the colon. Cancer Res 69: 9118-9124.

Venditto, V.J., Allred, K., Allred, C.D., and Simanek, E.E. 2009. Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: a general strategy toward drug delivery vehicles. Chemical Communications: 5541-5542.

Allred, K.F., Yackley, K.M., Vanamala, J., and Allred, C.D. 2009. Trigonelline is a novel phytoestrogen in coffee beans. J Nutr 139: 1833-1838.

Wang, X., Southard, R.C., Allred, C.D., Talbert, D.R., Wilson, M.E., and Kilgore, M.W. 2008. MAZ drives tumor-specific expression of PPAR gamma 1 in breast cancer cells. Breast Cancer Res Treat 111: 103-111.

Wang, V.C., Sable, H.J.K., Ju, Y.H., Allred, C.D., Helferich, W.G., Korol, D.L., and Schantz, S.L. 2008. Effects of chronic estradiol treatment on delayed spatial alternation and differential reinforcement of low rates of responding. Behavioral Neuroscience 122: 794-804.

Talbert, D.R., Allred, C.D., Zaytseva, Y.Y., and Kilgore, M.W. 2008. Transactivation of ERalpha by Rosiglitazone induces proliferation in breast cancer cells. Breast Cancer Res Treat 108: 23-33.

Allred, C.D., Talbert, D.R., Southard, R.C., Wang, X., and Kilgore, M.W. 2008. PPARgamma1 as a molecular target of eicosapentaenoic acid in human colon cancer (HT-29) cells. J Nutr 138: 250-256.

Ju, Y.H., Allred, K.F., Allred, C.D., and Helferich, W.G. 2006. Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations. Carcinogenesis 27: 1292-1299.

Allred, C.D., Twaddle, N.C., Allred, K.F., Goeppinger, T.S., Churchwell, M.I., Ju, Y.H., Helferich, W.G., and Doerge, D.R. 2005. Soy processing affects metabolism and disposition of dietary isoflavones in ovariectomized BALB/c mice. J Agric Food Chem 53: 8542-8550.

Allred, C.D. and Kilgore, M.W. 2005. Selective activation of PPARgamma in breast, colon, and lung cancer cell lines. Mol Cell Endocrinol 235: 21-29.

Allred, C.D., Allred, K.F., Ju, Y.H., Goeppinger, T.S., Doerge, D.R., and Helferich, W.G. 2004. Soy processing influences growth of estrogen-dependent breast cancer tumors. Carcinogenesis 25: 1649-1657.

Allred, C.D., Allred, K.F., Ju, Y.H., Clausen, L.M., Doerge, D.R., Schantz, S.L., Korol, D.L., Wallig, M.A., and Helferich, W.G. 2004. Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovariectomy of Sprague-Dawley rats. Carcinogenesis 25: 211-218.

Yellayi, S., Naaz, A., Szewczykowski, M.A., Sato, T., Woods, J.A., Chang, J.S., Segre, M., Allred, C.D., Helferich, W.G., and Cooke, P.S. 2002. The phytoestrogen genistein induces thymic and immune changes: A human health concern? Proceedings of the National Academy of Sciences of the United States of America 99: 7616-7621.

Ju, Y.H., Doerge, D.R., Allred, K.F., Allred, C.D., and Helferich, W.G. 2002. Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice. Cancer Res 62: 2474-2477.

Ju, Y.H., Allred, C.D., Allred, K.F., Karko, K.L., Doerge, D.R., and Helferich, W.G. 2001. Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice. J Nutr 131: 2957-2962.

Allred, C.D., Ju, Y.H., Allred, K.F., Chang, J., and Helferich, W.G. 2001. Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein. Carcinogenesis 22: 1667-1673.

Allred, C.D., Allred, K.F., Ju, Y.H., Virant, S.M., and Helferich, W.G. 2001. Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dose-dependent manner. Cancer Res 61: 5045-5050.

Publications from Genetics Graduate Students:

Weige, C.C., Allred, K.F., and Allred, C.D. 2009. Estradiol alters cell growth in nonmalignant colonocytes and reduces the formation of preneoplastic lesions in the colon. Cancer Res 69: 9118-9124.