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Camille Duran

Camille Duran

Advisor: Dr. Kayla Bayless

Health Science Center
Department of Molecular and Cellular Medicine

Education:

  1. B.S., Molecular Biology, Ohio State University, June 2011

Biography:

Entered the program in 2011

Research Project:

I am studying the mechanisms by which noncanonical NF-kB signaling promotes glioma cell invasion. Using gene overexpression studies, and examination of mRNA and protein expression during glioma invasion into 3D collagen matrices, we are studying how NF-kB signaling controls the expression and activity of key molecules to regulate invasive behavior.

I am also investigating the regulation of cytoskeletal proteins during endothelial cell sprouting into 3D collagen matrices.

Broader Impacts of Research Project:

High-grade gliomas are the most common primary brain tumor, characterized as highly invasive, aggressive, and resistant to current therapies, leading to a poor prognosis. The median survival of patients with high-grade glioma is one year. Previous studies have found noncanonical NF-kB signaling activation is correlated with glioma invasiveness. Therefore, a better understanding of the mechanisms through which noncanonical NF-kB signaling promotes invasiveness could aid in the development of therapies to combat this deadly tumor. 

Research Interest:

Medical Genetics